March 17 th


Schmidt’s Syndrome in dogs

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Carson is doing GREAT on a small dosage of prednisone and cortisol. He is singing for his meals and is more alert and active than he has been in several months.  Here is info from Dr. Jean Dodds. We are so glad we recognized the signs of adrenal failure before it was too late.

Polyglandular Autoimmunity (by Jean Dodds, DVM)

Individuals genetically susceptible to autoimmune thyroid disease may also become more susceptible to immune-mediated diseases affecting other target tissues and organs, especially the bone marrow, liver, adrenal gland, pancreas, skin, kidney, joints, bowel, and central nervous system. The resulting “polyglandular autoimmune syndrome” of humans is becoming more commonly recognized in the dog, and probably occurs in other species as well. The syndrome tends to run in families and is believed to have an inherited basis. Multiple endocrine glands and nonendocrine systems become involved in a systemic immune-mediated process. This multiple endocrinopathy often occurs in patients with underlying autoimmune thyroid disease (hypo- or hyperthyroidism) and concurrent Addison’s disease, diabetes, reproductive gonadal failure, skin disease and alopecia, and malabsorption syndrome. The most common nonendocrinologic autoimmune disorders associated with this syndrome are autoimmune hemolytic anemia (AIHA), idiopathic thrombocytopenic purpura (ITP), chronic active hepatitis, and immune-complex glomerulonephritis (systemic lupus erythematosus; SLE).

The most commonly recognized polyglandular endocrinopathy of dogs is Schmidt’s syndrome (thyroiditis and Addison’s disease).

Here is Addison’s info:

Hypoadrenocorticism (Addison’s disease): The adrenal gland produces hormones that are needed to maintain proper cell function. Their loss is seen as muscle weakness and eventually heart failure as the heart’s muscle cells can no longer produce the neurological impulses needed for the heart contractions. Gastrointestinal function is usually affected as well, and weight loss is frequently seen. The symptoms can be subtle until the dog just collapses in shock. Animals are less able to cope with mild, everyday occurrences and hide, refuse to eat, and show other symptoms of stress

Carson singing for his breakfast

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